Cardarine or GW1516 GW501516 or Endurobol is a synthetic chemical, that has been shown to improve nutritional and metabolic processes, normalize blood sugar levels, as well as affect physical performance.

The literature explore how it changes the ways by which the body processes fats. That is why the substance has been especially popular among professional athletes in their desire to achieve better results in performances.

What is Cardarine?

Cardarine is an altered compound popularly known as GW501516 and acts as a metabolic performance enhancer some people believe that it is SARM (selective androgen receptor modulator), and though it exists under cardarine family, it is a PPAR (peroxisome proliferator-activated receptor) agonist. The cell receptors these affect are most plentiful in muscle tissue all over the body.

Stemming from fatty acid derivatives, compounds like Cardarine impact on energy metabolism within cells and are supposed to boost energy utilization.

This is why some athletes and bodybuilders are interested in taking Cardarine. Many people may consume it to enhance their fat loss, have a thin muscular body as well as boost their sporting performance.

Purported Benefits Of Cardarine

Different authors have noted that some of the uses of Cardarine include the following health and performance enhancement.

It is also imperative to note that many of those experiments were done on animals and thus these results might not transfer to people.

1. Weight loss

Two major so-called advantages of taking Cardarine are weight loss and fat loss. On paper, it might be able to enhance the trainees’ fat loss rate and capacity as well.

This might be the case because the drug has a metabolic function. After all, it is associated with a part of the cell that is responsible for metabolism.

The first research on Cardarine was conducted in its attempts to be an obesity drug. Thus, an older study in mice associated Cardarine with increased fatty acid oxidation and reduced fat storage, thus the mice fed with a high-calorie diet had a lower incidence of obesity (2Trusted Source).

Scientists then showed that Cardarine may activate the PPAR biomolecule in the same manner as exercise so that if taken, Cardarine would seemingly have the impact of exercise in the body (3Trusted Source, 4Trusted Source, 5Trusted Source, 6Trusted Source).

If that were the case, then it means people could use Cardarine to gain some of the benefits of exercising with no need to exercise at all. However, what again is lacking is there are no good quality, durable human studies to suggest the efficacy of this on our bodies.

2. Advantages for diabetics

Scientists also studied Cardarine in the treatment of type II diabetes, a disease resulting from insulin insensitivity, or diabetes mellitus, where the body does not properly metabolize carbohydrates.

In a more recent one, researchers administered Cardarine to rodents in order to examine its impact on gestational diabetes, a condition characterized by high blood sugar levels in pregnant people (7Trusted Source).

The researchers discovered that in rats, gestational diabetes as well as Cardarine resulted into; increased blood glucose and insulin levels, and reduced damage to islet cells- cells that are located in the pancreas and are responsible for producing insulin.

Lastly, one study has discovered that Cardarine can enhance wound healing in diabetic wounds since the latter is a common ailment in advanced diabetes patients that results in reduced blood flow to some parts of the body.

As you can observe from the lit review most of the research done in this area is in animals. Therefore, the outcomes, although promising, cannot be used on humans and further studies have to be performed.

3. May improve blood fat levels

There were some theoretical uses for Cardarine in the early days to help with blood lipid levels including cholesterol and risky fatty acids known as triglycerides.

This relation has been severally established in older literature to exist between the PPAR pathway and fat oxidation (9Trusted Source, 10Trusted Source, 11Trusted Source, 12Trusted Source).

However, no more than a few experiments have mentioned how Cardarine, for example, can impact fats in the blood.

There is one human trial conducted in 2007 which made 24 healthy subjects take a placebo, 2.5 mg Cardarine, and 10 mg Cardarine per day for 14 days (13Trusted Source).

According to them, the population that sampled Cardarine showed an increase in the High-Density Lipoprotein Cholesterol (HDLC) levels in the same population and a decrease in the total Blood triglyceride levels.

Nevertheless, these results are encouraging, but these comparisons have not been made in a large sample or on a long-term basis; therefore, the following recommendations are made.

4. Sports performance

One of the more apparent purposes people have been using Cardarine for has been in sports enhancement.

Because of this kind of fat-burning assistance, many athletes have considered using it in order to achieve the desired lean and muscular look as well as enhanced energy and cardiovascular performance.

Certain individuals describe it as a tool for enhancing stamen, endurance, workout performance, and fat loss among many others within days.

However, these claims are not grounded in solid research evidence with only a few studies done on animals existing.

Side effects

One factor that poses a question when it comes to the use of Cardarine is that of side effects.

When studying the compound in its early stages of discovery, it was established that Cardarine could create and rapidly promote tumor mass in mice and rats, given in dosages of 1.4 mg per pound of body weight per a single day (3 mg per kg of body weight per day).

At this stage, large pharmaceutical companies that previously sponsored the drug research withdrew further experiments on it.

Personally, it is also important to note that this is a higher dose compared with the doses that have been used in humans.

Unfortunately, much about them remains unknown in humans, tubular injury is just one of the many side effects of Cardarine, and given that the study of this drug is quite scarce, it would be quite dangerous to use Cardarine.

How Much To Take Cardarine

Since there is no reliable human data available regarding the use of Cardarine, and since the side effects are dubious at best, it should come as no surprise that it’s tough to know how much to take.

Cardarine dosages ranged from 2.5 10 mg in the participants of the limited human trials, all with negligible side impacts. Nonetheless, these investigations have not been repeated so additional research is required to elucidate these observations (13Trusted Source, 16).

As a result of limited research and unreliable information, the use of Cardarine is inadvisable.

Where To Find Cardarine

Because Cardarine has not been tested clinically, and it falls under the prohibited list by many sports associations all over the world, large pharma companies do not manufacture it.

Thus, its availability is a real rarity with an exception for a few black market laboratories. A number of illegitimate supplement providers offer what they refer to as Cardarine on the internet, most of them with low reputation and third-party testing.

These products may therefore be fake and vulnerable to contamination.

Conclusion

Cardarine refers to GW501516 and has been under discussion mainly due to its benefits in boosting metabolism, increasing fat burning, and offering improved muscle performance.

It even states that preliminary animal research has established how it helps with overweight and obesity, diabetes, and blood cholesterol; but regrettably, these effects remain theoretical because insufficient trials have been conducted on people.

However, since it is linked to tumor formation in animal trials, it has great controversy as well as risk for use.

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